Pharmacogenetics and adverse drug reactions.

I-33: Pharmacogenetics of Reproductive Medicine

Adverse drug reactions (ADRs) are a major problem in drug therapy and drug development. Inter-individual genetic differences can have significant roles in determining an individual’s susceptibility to ADRs. The rapid development of techniques in the area of genome analysis has put the scientific community in a power position and facilitated identification of new pharmacogenomic biomarkers that ...

Pharmacogenetics and Antipsychotic Treatment in Schizophrenia with Special Focus on Adverse Drug Reactions

ADRIS--The Adverse Drug Reactions Information Scheme.

Under the Adverse Drug Reactions Information Scheme (ADRIS) data and knowledge relevant to the etiology of adverse drug reactions (ADRs) such as chemical structure of parent compounds, metabolites, covalent adducts, nucleic acid and protein sequences, protein structures, pharmaco-, toxico- and enzyme kinetics, pharmaco- and toxicodynamics, protein interactions, molecular pathways and complexes,...

Pharmacogenetics and Predictive Testing of Drug Hypersensitivity Reactions

Adverse drug reactions adverse drug reaction (ADR) occur in approximately 17% of patients. Avoiding ADR is thus mandatory from both an ethical and an economic point of view. Whereas, pharmacogenetics changes of the pharmacokinetics may contribute to the explanation of some type A reactions, strong relationships of genetic markers has also been shown for drug hypersensitivity belonging to type B...

Pharmacogenetics In Dose Individualization In Diabetes, Psychiatry, Cancer And Cardiology

Following administration of any medication, it is not always possible to predict its effects in the individual patient. Due to the major inter-individual variability in response to pharmacotherapy, in some patients, adverse drug reactions or therapeutic failure instead of therapeutic success are observed. The list of possible factors contributing to the individual drug response involves e.g. ag...